Pappata S, Levasseur M, Gunn R N, Myers R, Crouzel C, Syrota A, Jones T, Kreutzberg G W, Banati R B
INSERM U334, Service Hospitalier Frédéric Joliot, Orsay, France.
Neurology. 2000 Oct 10;55(7):1052-4. doi: 10.1212/wnl.55.7.1052.
Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
作者使用定量PET研究了[11C]PK11195（一种活化小胶质细胞的标志物）在慢性大脑中动脉梗死患者丘脑的结合情况。所有患者同侧丘脑的[11C]PK11195结合均增加，表明远离原发性病变的退化投射区域中小胶质细胞被激活。[11C]PK11195结合的持续增加提示皮质丘脑连接损伤后丘脑存在活跃的长期微观结构变化。
