Foster R S, Hermans B, Bihrle R, Donohue J P
Department of Urology, Indiana University Medical Center, Indianapolis, Indiana, USA.
J Urol. 2000 Dec;164(6):1943-4.
We evaluated the clinical behavior of clinical stage I pure yolk sac tumor of the testis in adults to determine whether the behavior of this entity is different than that of clinical stage 1 nonseminoma.
We searched the testis cancer database at our institution for adults with clinical stage I pure yolk sac tumor of the testis who underwent retroperitoneal lymph node dissection. We identified 12 such patients and reviewed the database and hospital charts to determine clinical behavior.
Disease was pathological stage I in 8 of the 12 patients (66%), including 1 with recurrence after retroperitoneal lymph node dissection. Disease was pathological stage II in 14 patients (33%), including 1 who remains disease-free after electing adjuvant bleomycin, etoposide and cisplatin. Of the 3 patients who elected observation after retroperitoneal lymph node dissection only 1 has had recurrence, while 2 (66%) were cured by retroperitoneal lymph node dissection only.
Contrary to juvenile yolk sac tumor, which has a strong tendency toward hematogenous metastasis, the behavior of clinical stage I adult pure yolk sac tumor is similar to that of all other stage I nonseminomas in adulthood.
我们评估了成人临床I期睾丸纯卵黄囊瘤的临床行为，以确定该实体的行为是否与临床I期非精原细胞瘤不同。
我们在本机构的睾丸癌数据库中搜索了接受腹膜后淋巴结清扫术的临床I期睾丸纯卵黄囊瘤成人患者。我们确定了12例此类患者，并查阅了数据库和医院病历以确定临床行为。
12例患者中有8例（66%）疾病处于病理I期，其中1例在腹膜后淋巴结清扫术后复发。14例患者（33%）疾病处于病理II期，其中1例在选择辅助使用博来霉素、依托泊苷和顺铂后无疾病复发。在3例腹膜后淋巴结清扫术后选择观察的患者中，只有1例复发，而2例（66%）仅通过腹膜后淋巴结清扫术治愈。
与具有强烈血行转移倾向的青少年卵黄囊瘤相反，临床I期成人纯卵黄囊瘤的行为与成年期所有其他I期非精原细胞瘤相似。
