Chuah K L, Tan P H, Hwang S G, Ong B H
Department of Pathology, Singapore General Hospital, Singapore.
Singapore Med J. 2000 Mar;41(3):122-5.
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare but distinct clinicopathologic entity characterised histologically by a benign s histiocytic proliferation. Isolated involvement of extranodal sites without concomitant nodal disease is rare. We describe the pathological features of 2 cases of Rosai-Dorfman disease that were clinically confined to the skin. In both male adult Chinese patients, proliferation of histiocytes was accompanied by S-100 protein expression demonstrated immunohistochemically within the histiocytes. The pathology of Rosai-Dorfman disease and its microscopic differential diagnoses are discussed.
罗萨伊-多夫曼病，也称为伴有巨大淋巴结病的窦性组织细胞增生症，是一种罕见但独特的临床病理实体，组织学特征为良性组织细胞增生。结外部位单独受累而无伴随的淋巴结疾病很罕见。我们描述了2例临床上局限于皮肤的罗萨伊-多夫曼病的病理特征。在两名成年中国男性患者中，组织细胞增生伴有免疫组化显示组织细胞内S-100蛋白表达。本文讨论了罗萨伊-多夫曼病的病理学及其显微镜下鉴别诊断。
