Annessi G, Giannetti A
Clinica Dermatologica Università di Modena, Istituto Dermopatico dell'Immacolata IRCCS, Roma, Italy.
Br J Dermatol. 1996 Apr;134(4):749-53.
Cutaneous lesions of Rosai-Dorfman disease (RDD) are usually associated with nodal or other extranodal localization. We describe a female patient with RDD clinically limited to the skin. The patient presented with asymptomatic red-brown papules and nodules on the legs, arms, back, and nose. Histologically, the lesions consisted of a proliferation of large histiocytes occasionally showing emperipolesis. Histiocytes were also observed within dilated lymphatic vessels. Immunohistochemical study showed that histiocytes expressed S-100 protein and both macrophage and monocyte markers. All lesions resolved completely with Roentgen therapy. No recurrence has been observed over a 3-year follow-up period.
罗萨伊-多夫曼病（RDD）的皮肤病变通常与淋巴结或其他结外部位受累相关。我们描述了一名临床上仅局限于皮肤的RDD女性患者。该患者双下肢、双臂、背部及鼻部出现无症状的红棕色丘疹和结节。组织学上，病变由大量组织细胞增生构成，偶尔可见吞噬现象。在扩张的淋巴管内也观察到了组织细胞。免疫组化研究显示组织细胞表达S-100蛋白以及巨噬细胞和单核细胞标志物。所有病变经X线治疗后完全消退。在3年的随访期内未观察到复发。
