Paracha P I, Jamil A, Northrop-Clewes C A, Thurnham D I
Department of Nutrition, Agricultural University and Goverment Department of Health, Peshawar, North West Frontier Province, Pakistan.
Am J Clin Nutr. 2000 Nov;72(5):1164-9. doi: 10.1093/ajcn/72.5.1164.
Plasma retinol concentrations are depressed by infection but are commonly used to assess vitamin A status.
We measured 2 acute phase proteins, alpha(1)-antichymotrypsin (ACT) and alpha(1)-acid glycoprotein (AGP), to determine whether they could be used to assist in interpreting vitamin A status.
In 1997, a 2-stage cluster-sampling procedure was used to select 3074 apparently healthy, 6-60-mo-old children from rural and urban areas of North West Frontier Province, Pakistan. Plasma retinol, ACT, AGP, and ferritin measurements and anthropometric measurements were obtained for 2519 children.
Median plasma retinol, ACT, AGP, and ferritin concentrations were 0.86 micromol/L, 0.39 g/L, 1.14 g/L, and 5.5 microg/L, respectively. There were no significant (P: > 0.05) differences in retinol, ACT, or AGP by sex or age. Some 797 children (32%) had retinol concentrations <0.7 micromol/L and 87 (4%) had retinol concentrations <0.35 micromol/L; 274 children (11%) had elevated ACT (>0.6 g/L) and 1141 (45%) had elevated AGP (>1.2 g/L). Retinol concentration correlated with ACT (r = -0.141), AGP (r = -0.138), and ferritin (r = -0.09) (all P: < 0.001), but stepwise multiple regression indicated that these 3 variables made a minimal although quantifiable contribution to the variance of retinol (ACT, r(2) = 0.02; all 3 variables, r(2) = 0.03).
The transient depression in plasma retinol produced by subclinical infection increased the number of at-risk children by 10% (76 of 797) and 56% (49 of 87) for plasma retinol concentrations <0.7 and <0.35 micromol/L, respectively. In addition, dietary inadequacy may be responsible for retinol concentrations being approximately 16% lower in Pakistani children than in children in the United Kingdom, where dietary vitamin A is adequate.
感染会降低血浆视黄醇浓度，但血浆视黄醇浓度通常用于评估维生素A状况。
我们检测了两种急性期蛋白，即α1抗糜蛋白酶（ACT）和α1酸性糖蛋白（AGP），以确定它们是否可用于辅助解读维生素A状况。
1997年，采用两阶段整群抽样程序，从巴基斯坦西北边境省农村和城市地区选取了3074名6至60月龄的貌似健康儿童。对其中2519名儿童进行了血浆视黄醇、ACT、AGP和铁蛋白检测以及人体测量。
血浆视黄醇、ACT、AGP和铁蛋白浓度中位数分别为0.86微摩尔/升、0.39克/升、1.14克/升和5.5微克/升。视黄醇、ACT或AGP在性别或年龄方面无显著差异（P>0.05）。约797名儿童（32%）血浆视黄醇浓度<0.7微摩尔/升，87名儿童（4%）血浆视黄醇浓度<0.35微摩尔/升；274名儿童（11%）ACT升高（>0.6克/升），1141名儿童（45%）AGP升高（>1.2克/升）。视黄醇浓度与ACT（r = -0.141）、AGP（r = -0.138）和铁蛋白（r = -0.09）相关（P均<0.001），但逐步多元回归表明这3个变量对视黄醇方差的贡献极小，尽管可量化（ACT，r2 = =0.02；3个变量，r2 = 0.03）。
亚临床感染导致的血浆视黄醇短暂降低，使血浆视黄醇浓度<0.7微摩尔/升和<0.35微摩尔/升的高危儿童数量分别增加了10%（797名中的76名）和56%（87名中的49名）。此外，饮食不足可能是巴基斯坦儿童视黄醇浓度比英国儿童低约16%的原因，英国儿童饮食中维生素A充足。
