[Influence of cortisone on the implantation of skin allotransplants].

Skin transplants of CC57 Brown mice to CBA mice different in strong antigens controlled by H-2 locus of histocompatibility were studied with special attention given to the division of epithelial cells. Five-day-long injecting of cortisone (single dose 2,5 mg) was performed in 2 variants of experiments: 2 days before or 3 days after operation. The mean day of rejection of the graft after injection of the hormone was prolonged from 6,9 to 17,8--19,8 days. Cortisone retarded development of the inflammatory reaction, formation of the granular tissue and decreased mitotic activity in the recipient's epithelium delaying its growth and thus the transplant elimination. Degenerative changes in the transplant tissues diminished, while the mitotic activity kept its sufficiently high level until rejection.