Svetikova K M, Shemerovskaia T G
Arkh Anat Gistol Embriol. 1975 May;68(5):106-13.
Skin transplants of CC57 Brown mice to CBA mice different in strong antigens controlled by H-2 locus of histocompatibility were studied with special attention given to the division of epithelial cells. Five-day-long injecting of cortisone (single dose 2,5 mg) was performed in 2 variants of experiments: 2 days before or 3 days after operation. The mean day of rejection of the graft after injection of the hormone was prolonged from 6,9 to 17,8--19,8 days. Cortisone retarded development of the inflammatory reaction, formation of the granular tissue and decreased mitotic activity in the recipient's epithelium delaying its growth and thus the transplant elimination. Degenerative changes in the transplant tissues diminished, while the mitotic activity kept its sufficiently high level until rejection.
对CC57棕色小鼠的皮肤移植到组织相容性H-2位点所控制的强抗原不同的CBA小鼠进行了研究，特别关注上皮细胞的分裂。在两种实验变体中进行了为期五天的可的松注射（单剂量2.5毫克）：手术前2天或手术后3天。注射激素后移植物排斥的平均天数从6.9天延长至17.8 - 19.8天。可的松延缓了炎症反应的发展、肉芽组织的形成，并降低了受体上皮中的有丝分裂活性，从而延迟其生长，进而延缓移植物的清除。移植组织中的退行性变化减少，而有丝分裂活性在排斥前一直保持足够高的水平。
