Thomas G K, Marsden J
Arch Otolaryngol. 1975 Nov;101(11):689-92. doi: 10.1001/archotol.1975.00780400047013.
Subglottic stenosis in the infant currently has no well-accepted surgical correction. Our experimental study was designed to determine the effectiveness of a nasal septal cartilage-mucosa autograft in increasing the subglottic circumference and its effect on subsequent subglottic growth. Six pairs of matched mongrel puppy litter mates were used; one underwent surgery, the other served as a control. The cricoid and first tracheal rings were split anteriorly, and widened 5 mm to accept an autogenous nasal septal cartilage-mucosa graft. All animals were killed after six months of postoperative growth. The autografts appeared to be partially or completely replaced by fibrous tissue but a persistent enlargement in the subglottic airway was found in the animals that underwent surgery, with glottic measurements the same in both groups. Thus, a septal cartilage autograft to the subglottic larynx in puppies appears to result in persistent enlargement of the subglottic area, but produces no interference with subsequent normal laryngeal growth and development.
目前，婴儿声门下狭窄尚无广泛认可的手术矫正方法。我们的实验研究旨在确定鼻中隔软骨-黏膜自体移植物在增加声门下周长方面的有效性及其对后续声门下生长的影响。使用了六对匹配的杂种幼犬同窝仔；一对接受手术，另一对作为对照。环状软骨和第一气管环在前部劈开，并加宽5毫米以接受自体鼻中隔软骨-黏膜移植物。所有动物在术后生长六个月后处死。自体移植物似乎部分或完全被纤维组织替代，但在接受手术的动物中发现声门下气道持续扩大，两组的声门测量结果相同。因此，幼犬声门下喉部的鼻中隔软骨自体移植似乎会导致声门下区域持续扩大，但不会干扰随后的正常喉部生长和发育。
