Saraçoglu F, Sahin I, Eser E, Göl K, Türkkani B
Ankara Numune Education and Research Hospital, Obstetric and Gynecology Clinic, Ankara, Turkey.
Int J Gynaecol Obstet. 2000 Nov;71(2):113-8. doi: 10.1016/s0020-7292(00)00259-9.
To investigate the variations of nucleated red blood cell (NRBC) counts in acute and chronic fetal hypoxia and to examine if it could be possible to establish a cutoff value for the number of NRBCs for prediction of fetal acidosis.
We prospectively studied 77 pregnant women. Patients were grouped as acute (n=11) and chronic fetal distress (n=21) and controls (n=45). At delivery the umbilical cord was double clamped and blood samples were collected.
The mean NRBC counts in chronic fetal distress group was higher than acute fetal distress. NRBC counts were found to be correlated with umbilical cord pH (r=-0.57; P<0.001). The cutoff value predicting fetal acidosis was determined as 14/100 leukocytes (sensitivity 87%, specificity 81%) by using ROC analysis.
The duration and the severity of fetal asphyxia may be predicted by the number of NRBCs per leukocyte.
研究急性和慢性胎儿缺氧时核红细胞（NRBC）计数的变化，并探讨是否有可能建立一个NRBC数量的临界值以预测胎儿酸中毒。
我们前瞻性地研究了77名孕妇。患者被分为急性组（n = 11）、慢性胎儿窘迫组（n = 21）和对照组（n = 45）。分娩时，脐带双重钳夹并采集血样。
慢性胎儿窘迫组的平均NRBC计数高于急性胎儿窘迫组。发现NRBC计数与脐带pH值相关（r = -0.57；P < 0.001）。通过ROC分析，预测胎儿酸中毒的临界值确定为每100个白细胞中有14个NRBC（敏感性87%，特异性81%）。
每白细胞中NRBC的数量可预测胎儿窒息的持续时间和严重程度。
