球形芽孢杆菌对孕酮侧链的裂解作用。
Progesterone side-chain cleavage by Bacillus sphaericus.
作者信息
Wadhwa L, Smith K E
机构信息
Molecular and Cellular Biology, Division of Biomedical Sciences, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Mile End Road, E1 4NS, London, UK.
出版信息
FEMS Microbiol Lett. 2000 Nov 15;192(2):179-83. doi: 10.1111/j.1574-6968.2000.tb09379.x.
Abstract
The side-chain of progesterone was cleaved by Bacillus sphaericus to produce two C-19 keto androstene steroids. The structures of these metabolites were androstenedione and 1-dehydroandrostenedione. High concentrations of glucose in the culture medium inhibited conversion of progesterone to these two metabolites.
摘要
球形芽孢杆菌可裂解孕酮的侧链，生成两种C-19酮基雄烯类固醇。这些代谢产物的结构分别是雄烯二酮和1-脱氢雄烯二酮。培养基中高浓度的葡萄糖会抑制孕酮向这两种代谢产物的转化。
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