Anteneh Yitayal Shiferaw, Franco Christopher Milton Mathew
College of Medicine and Public Health, Medical Biotechnology, Flinders University, Bedford Park, SA, Australia.
Department of Medical Microbiology, College of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Front Microbiol. 2019 Feb 18;10:77. doi: 10.3389/fmicb.2019.00077. eCollection 2019.
Production of fuels, therapeutic drugs, chemicals, and biomaterials using sustainable biological processes have received renewed attention due to increasing environmental concerns. Despite having high industrial output, most of the current chemical processes are associated with environmentally undesirable by-products which escalate the cost of downstream processing. Compared to chemical processes, whole cell biocatalysts offer several advantages including high selectivity, catalytic efficiency, milder operational conditions and low impact on the environment, making this approach the current choice for synthesis and manufacturing of different industrial products. In this review, we present the application of whole cell actinobacteria for the synthesis of biologically active compounds, biofuel production and conversion of harmful compounds to less toxic by-products. Actinobacteria alone are responsible for the production of nearly half of the documented biologically active metabolites and many enzymes; with the involvement of various species of whole cell actinobacteria such as and for the production of useful industrial commodities.
由于环境问题日益受到关注，利用可持续生物过程生产燃料、治疗药物、化学品和生物材料再次受到关注。尽管目前的大多数化学过程具有较高的工业产量，但它们大多会产生对环境不利的副产品，这增加了下游加工的成本。与化学过程相比，全细胞生物催化剂具有几个优点，包括高选择性、催化效率、较温和的操作条件以及对环境的低影响，使得这种方法成为目前合成和制造不同工业产品的选择。在这篇综述中，我们介绍了全细胞放线菌在生物活性化合物合成、生物燃料生产以及将有害化合物转化为毒性较小的副产品方面的应用。仅放线菌就负责生产近一半已记录的生物活性代谢物和许多酶；各种全细胞放线菌物种，如 和 参与了有用工业商品的生产。
