Jackson P G, Evans S R
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
J Surg Oncol. 2000 Oct;75(2):146-54. doi: 10.1002/1096-9098(200010)75:2<146::aid-jso14>3.0.co;2-1.
The macrophage (Mphi) is considered the first line of defense in immune response to foreign invaders. Increasing evidence suggests that Mphi(s) also play an important role against neoplastic cells. Mphi(s) exposed to supraphysiologic concentrations of CO(2) are suppressed. As surgeons apply newer minimally invasive techniques to oncologic therapies, it is important to evaluate the impact of these techniques on host-tumor interactions. We review the current understanding of Mphi biology with specific attention on cytotoxicity in addition to tumor immunity. Although systemic immune function is better preserved after laparoscopy than laparotomy, peritoneal Mphi(s) show reduced function after CO(2) pneumoperitoneum than exposure to air. Mphi(s) have shown cytotoxicity to syngeneic cancer cells and may play an important role in tumor surveillance. The impairment in Mphi function after CO(2) exposure may have an effect on outcome after oncologic surgery. In our understanding, Mphi(s) help destroy neoplastic cells. As CO(2) impairs Mphi activity, laparoscopy may significantly alter the host-tumor interaction.
巨噬细胞（Mphi）被认为是对外来入侵者免疫反应的第一道防线。越来越多的证据表明，Mphi在对抗肿瘤细胞方面也发挥着重要作用。暴露于超生理浓度二氧化碳的Mphi会受到抑制。随着外科医生将更新的微创技术应用于肿瘤治疗，评估这些技术对宿主-肿瘤相互作用的影响非常重要。我们回顾了目前对Mphi生物学的理解，特别关注除肿瘤免疫外的细胞毒性。虽然腹腔镜检查后全身免疫功能比剖腹手术更好地保留，但二氧化碳气腹后腹膜Mphi的功能比暴露于空气后降低。Mphi已显示出对同基因癌细胞的细胞毒性，并可能在肿瘤监测中发挥重要作用。二氧化碳暴露后Mphi功能的损害可能会对肿瘤手术后的结果产生影响。据我们了解，Mphi有助于破坏肿瘤细胞。由于二氧化碳会损害Mphi的活性，腹腔镜检查可能会显著改变宿主-肿瘤相互作用。
