Jaisser F
INSERM Unit 478, Medicine Faculty Xavier Bichat, Paris, France.
J Am Soc Nephrol. 2000 Nov;11 Suppl 16:S95-S100.
Animal transgenesis has proven to be useful for physiologic as well as pathophysiologic studies. Animal models with conditional expression of a transgene of interest or with a conditional gene mutation can be generated. This permits spatial and temporal control of the expression of the transgene or of gene mutations previously introduced by gene targeting. These approaches allow the generation of models suitable for physiologic analysis or models mimicking disease states.
动物转基因技术已被证明在生理学和病理生理学研究中都很有用。可以生成具有感兴趣的转基因条件性表达或具有条件性基因突变的动物模型。这允许对转基因的表达或先前通过基因靶向引入的基因突变进行空间和时间上的控制。这些方法使得适合生理学分析的模型或模拟疾病状态的模型得以产生。
