Goldman R I, Stern J M, Engel J, Cohen M S
UCLA Brain Mapping Division, Ahmanson-Lovelace Brain Mapping Center, 660 Charles E. Young Drive South, Los Angeles, CA 90095-7085, USA.
Clin Neurophysiol. 2000 Nov;111(11):1974-80. doi: 10.1016/s1388-2457(00)00456-9.
Electroencephalography (EEG) is a challenge to record simultaneously with functional MRI (fMRI), for it is prone to large artifacts induced by both the static and the time-variant fields of the MR scanner. However, truly concurrent EEG/fMRI recording has great potential for clinical and scientific neurological applications. We have devised a method for acquiring EEG simultaneously with fMRI that minimizes contamination of the EEG signals.
We recorded EEG differentially during fMRI using special twisted dual-lead electrodes in a bipolar montage, and a combination of analog pre-processing and digital post-processing of the EEG data. We implemented a functional scan protocol that typically yields artifact-free EEG over 87% of the MR scanning period.
Our approach greatly reduced gradient, radio frequency, motion and ballistocardiographic artifact in the EEG, and allowed continuous monitoring of the EEG during functional scanning. To illustrate the quality of the EEG following post-processing, we demonstrated that EEG recorded during fMRI retains useful spectral information.
Quality EEG may be recorded simultaneously with fMRI. With this union, activation maps could be made of any relevant changes in the EEG, such as inter-ictal spikes or spectral variations, or of evoked response potentials (ERPs).
脑电图（EEG）与功能磁共振成像（fMRI）同时记录具有挑战性，因为它容易受到磁共振扫描仪的静态和时变场诱发的大量伪影影响。然而，真正同步的EEG/fMRI记录在临床和科学神经学应用中具有巨大潜力。我们设计了一种与fMRI同时采集EEG的方法，可将EEG信号的污染降至最低。
我们在fMRI期间使用特殊的双股绞合双导联电极以双极导联方式差分记录EEG，并对EEG数据进行模拟预处理和数字后处理相结合的操作。我们实施了一种功能扫描方案，该方案通常在87%以上的磁共振扫描期间产生无伪影的EEG。
我们的方法大大减少了EEG中的梯度、射频、运动和心冲击图伪影，并允许在功能扫描期间持续监测EEG。为了说明后处理后EEG的质量，我们证明了在fMRI期间记录的EEG保留了有用的频谱信息。
可以与fMRI同时记录高质量的EEG。通过这种结合，可以根据EEG的任何相关变化制作激活图，例如发作间期棘波或频谱变化，或诱发电位（ERP）。
