Leikin S, Bernstein I, Evans A, Finklestein J, Hittle R, Klemperer M
Cancer Chemother Rep. 1975 Sep-Oct;59(5):1015-8.
Adriamycin and DTIC were used in combination because of their reported effectiveness in neuroblastoma when administered as single agents and because of the poor survival rate of patients with this malignancy in its disseminated stage. Eighteen patients with previously treated stage IV neuroblastoma received this combination chemotherapy every 21 days. Two to eight courses were administered. Two partial and no complete remissions were seen. Mild to moderate gastrointestinal and hematologic toxicity was observed.
阿霉素和氮烯咪胺联合使用是因为据报道它们单独使用时对神经母细胞瘤有效，也因为这种恶性肿瘤处于播散期时患者的生存率很低。18例先前接受过治疗的IV期神经母细胞瘤患者每21天接受一次这种联合化疗。共进行了2至8个疗程。观察到2例部分缓解，无完全缓解病例。观察到轻至中度的胃肠道和血液学毒性。
