Cangir A, Morgan S K, Land V J, Pullen J, Starling S A, Nitschke R
Med Pediatr Oncol. 1976;2(2):183-90. doi: 10.1002/mpo.2950020208.
Combination chemotherapy with adriamycin and DTIC was used in 102 evaluable patients under 15 years of age who had previously treated metastatic solid tumors. Responses, defined as 50% or more reduction in all tumor masses, occurred in 10 out of 27 patients with neuroblastoma, 3 out of 8 patients with Wilms tumor, 7 out 15 patients with Ewing sarcoma, 2 out of 6 patients with osteosarcoma, 5 out of 13 patients with rhabdomyosarcoma, and 15 out of 33 patients with miscellaneous tumors which included a patient who had a complete regression of an extensive juvenile angiofibroma. Response rate to combination chemotherapy with adriamycin and DTIC in patients with Ewing sarcoma was significantly superior to the response rate obtained with adriamycin alone in another Southwest Oncology Group Study. Major toxicity included nausea, vomiting, myelosuppression, high incidence of pneumocystis carinii pneumonia (5 patients) and congestive heart failure (4 patients). There was 7 drug-associated deaths due to sepsis (1), pneumocystis carinii pneumonia (4), and congestive heart failure (2).
阿霉素和达卡巴嗪联合化疗应用于102例15岁以下曾接受过治疗的转移性实体瘤患者。疗效定义为所有肿瘤肿块缩小50%或更多，27例神经母细胞瘤患者中有10例出现疗效，8例肾母细胞瘤患者中有3例，15例尤因肉瘤患者中有7例，6例骨肉瘤患者中有2例，13例横纹肌肉瘤患者中有5例，33例其他肿瘤患者中有15例（其中1例广泛的青少年血管纤维瘤患者完全缓解）。在另一项西南肿瘤协作组研究中，尤因肉瘤患者接受阿霉素和达卡巴嗪联合化疗的缓解率显著高于单独使用阿霉素的缓解率。主要毒性包括恶心、呕吐、骨髓抑制、卡氏肺孢子虫肺炎发生率高（5例）和充血性心力衰竭（4例）。有7例与药物相关的死亡，原因分别为败血症（1例）、卡氏肺孢子虫肺炎（4例）和充血性心力衰竭（2例）。
