Douglass H O, Karakousis C
Cancer Chemother Rep. 1975 Sep-Oct;59(5):1045-7.
Fifteen patients with surgically incurable, advanced, and metastatic sarcomas were treated with courses of adriamycin and vincristine-actinomycin D alternating within a 7-week cycle. Three patients had objective partial responses for more than 3 months (liposarcoma, 4 months; fibrous histiocytoma, 15+ months; desmoid tumor, 19+ months) while two other patients (liposarcoma, leiomyosarcoma) had lesser responses. No beneficial effect could be attributed to therapy in two patients with leiomyosarcoma, two patients each with synovial cell sarcoma, fibrosarcoma, and chondrosarcoma, and one patient each with rhabdomyosarcoma and mesenchymoma. No additive effect of alternating full doses of these agents could be demonstrated over the published data on response to adriamycin or actinomycin D alone.
15例手术无法治愈的晚期转移性肉瘤患者接受了阿霉素和长春新碱-放线菌素D的疗程治疗，二者在7周的周期内交替使用。3例患者出现了超过3个月的客观部分缓解（脂肪肉瘤，4个月；纤维组织细胞瘤，15个多月；硬纤维瘤，19个多月），另有2例患者（脂肪肉瘤、平滑肌肉瘤）缓解程度较小。2例平滑肌肉瘤患者、2例滑膜细胞肉瘤患者、2例纤维肉瘤患者、2例软骨肉瘤患者、1例横纹肌肉瘤患者和1例间叶瘤患者未从治疗中获益。与已发表的单独使用阿霉素或放线菌素D的反应数据相比，无法证明交替使用这些药物的全剂量有累加效应。
