Mawhinney H, Love A H
Clin Exp Immunol. 1975 Sep;21(3):399-406.
An indirect immunofluorescent technique has been used to study the incidence and immunoglobulin class distribution of the serum antibody response to type II oral poliovaccine in patients with adult coeliac disease and matched control subjects. Nineteen out of thirty-eight (50%) patients with coeliac disease showed an antibody response compared with only seven out of thirty-eight (18%) control subjects. Poliovirus-specific IgA responses were observed in sixteen out of thirty-eight (42%) coeliac patients compared with seven out of thirty-eight (18%) control subjects, while poliovirus-specific IgG responses were observed in only ten out of thirty-eight (26%) coeliac patients and four out of thirty-eight (11%) control subjects. No poliovirus-specific IgM responses were observed. The pre-immunization poliovirus-specific IgA titres of those subjects who showed an antibody response were significantly higher in the coeliac group than in the control group.
采用间接免疫荧光技术研究成人乳糜泻患者和配对对照受试者对II型口服脊髓灰质炎疫苗血清抗体反应的发生率及免疫球蛋白类别分布。38例乳糜泻患者中有19例（50%）出现抗体反应，而38例对照受试者中只有7例（18%）出现抗体反应。38例乳糜泻患者中有16例（42%）观察到脊髓灰质炎病毒特异性IgA反应，而38例对照受试者中有7例（18%）观察到该反应；38例乳糜泻患者中只有10例（26%）观察到脊髓灰质炎病毒特异性IgG反应，38例对照受试者中有4例（11%）观察到该反应。未观察到脊髓灰质炎病毒特异性IgM反应。出现抗体反应的受试者中，乳糜泻组的免疫前脊髓灰质炎病毒特异性IgA滴度显著高于对照组。
