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乳糜泻和非乳糜泻患者体内的IgA和IgG网状纤维抗体

IgA and IgG reticulin antibodies in coeliac and non-coeliac patients.

作者信息

Eade O E, Lloyd R S, Lang C, Wright R

出版信息

Gut. 1977 Dec;18(12):991-3. doi: 10.1136/gut.18.12.991.

Abstract

Using indirect immunofluorescence, comparisons were made of patterns of staining of five tissue substrates with 28 RI reticulin antibody-positive coeliac sera, and 23 RI reticulin antibody-positive non-coeliac sera. IgA and IgG fluorescein conjugates were used separately. IgA antibodies were seen in 22 coeliac patients (78%) compared with three non-coeliacs (13%). Concomitant sinusoidal fluorescence (RS pattern) was seen more frequently with the non-coeliac (60.9%) than with the coeliac sera (10.7%). Such differences may help to distinguish those patients who should have a jejunal biopsy when using the reticulin antibody as a screening test for coeliac disease.

摘要

采用间接免疫荧光法,比较了28份网状纤维抗体阳性的乳糜泻血清和23份网状纤维抗体阳性的非乳糜泻血清对五种组织底物的染色模式。分别使用了IgA和IgG荧光素结合物。在22例乳糜泻患者(78%)中检测到IgA抗体,而在3例非乳糜泻患者(13%)中检测到IgA抗体。非乳糜泻血清(60.9%)比乳糜泻血清(10.7%)更频繁地出现伴随的窦状荧光(RS模式)。当使用网状纤维抗体作为乳糜泻的筛查试验时,这些差异可能有助于区分那些需要进行空肠活检的患者。

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