Barreto M L, Rodrigues L C, Silva R C, Assis A M, Reis M G, Santos C A, Blanton R E
Instituto de Saúde Coletiva/UFBa, Rua Padre Feijó, 29/4o andar-Canela 40.110-170 Salvador, Bahia Brazil.
J Infect Dis. 2000 Dec;182(6):1800-3. doi: 10.1086/317627. Epub 2000 Nov 8.
Bacillus Calmette-Guérin (BCG), the most common vaccine worldwide, has broad effects on the immune system. Hookworm infections are a major source of morbidity. In response to a preliminary report of BCG vaccination protection against nematodes in human immunodeficiency virus-infected adults, data from an ongoing prospective study were analyzed to determine the intensity (eggs per gram of stool), prevalence, and incidence of different helminths in children with and without a BCG vaccination scar. Adjusted prevalence and incidence ratios were estimated by using logistic regression. Children with a BCG vaccination scar were found to have statistically significantly lower hookworm prevalence (41%), incidence (37%), and mean egg counts (39%), after controlling for age, sex, and socioeconomic factors. There was no BCG association with incidence, prevalence, or intensity of infection with Schistosoma mansoni, Ascaris lumbricoides, or Trichuris trichiura. Such protection would have implications for public health and for research on mechanisms behind human immunological responses to hookworm.
卡介苗（BCG）是全球最常用的疫苗，对免疫系统有广泛影响。钩虫感染是发病的主要原因。针对一份关于卡介苗接种对人类免疫缺陷病毒感染成人线虫有保护作用的初步报告，分析了一项正在进行的前瞻性研究数据，以确定有或无卡介苗接种疤痕儿童中不同蠕虫的感染强度（每克粪便中的虫卵数）、感染率和发病率。采用逻辑回归估计调整后的感染率和发病率比值。在控制年龄、性别和社会经济因素后，发现有卡介苗接种疤痕的儿童钩虫感染率（41%）、发病率（37%）和平均虫卵计数（39%）在统计学上显著更低。卡介苗与曼氏血吸虫、蛔虫或鞭虫的感染发病率、感染率或感染强度无关联。这种保护作用将对公共卫生以及人类对钩虫免疫反应背后机制的研究产生影响。
