Turner R J, Walshaw D, Diffey B L, Farr P M
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K.
Br J Dermatol. 2000 Nov;143(5):957-63. doi: 10.1046/j.1365-2133.2000.03827.x.
Ultraviolet (UV) A sunbeds are widely used by patients with psoriasis in an attempt to treat their skin disease. However, there is little evidence that UVA therapy improves psoriasis, and the long-term risks of sunbed exposure are not known.
To perform a randomized, placebo-controlled study of UVA sunbed therapy for psoriasis.
A sunbed and canopy unit was modified to allow UVA exposure on one side of the body (front and back), and 'placebo' visible light exposure on the other side of the body. We treated 38 patients with psoriasis, giving 12 exposures over a period of 4 weeks. Assessment was made using a modified Psoriasis Area and Severity Index (PASI) score, individual plaque assessment and patient questionnaire.
In 17 patients (47%) the PASI score showed a greater reduction on the UVA side compared with placebo, in 11 patients (31%) no difference was recorded between the two sides, and in eight (22%) the improvement was greater on the placebo-treated side. Overall, the median pretreatment half-body modified PASI score was 4.4 units, reducing to 3.9 units on the UVA-treated side and 4.2 units on the placebo-treated side (P = 0. 044 for difference in response). Breakdown of the plaque score into the individual components of erythema, scale and thickness revealed significant improvement only with the score for erythema. Although the degree of improvement was small, 64% of patients felt that the response was sufficiently good that they would use a sunbed again to treat their psoriasis.
Our results show that a short course of sunbed treatment does improve psoriasis in some patients, but that the degree of improvement is small.
紫外线A（UVA）日光浴床被银屑病患者广泛使用，试图治疗他们的皮肤病。然而，几乎没有证据表明UVA疗法能改善银屑病，且日光浴床照射的长期风险尚不清楚。
进行一项关于UVA日光浴床治疗银屑病的随机、安慰剂对照研究。
对一个日光浴床和罩篷装置进行改造，使身体一侧（前后）接受UVA照射，另一侧接受“安慰剂”可见光照射。我们治疗了38例银屑病患者，在4周内进行12次照射。使用改良的银屑病面积和严重程度指数（PASI）评分、单个斑块评估和患者问卷进行评估。
17例患者（47%）的PASI评分显示，与安慰剂相比，UVA照射侧降低更明显；11例患者（31%）两侧无差异；8例患者（22%）安慰剂治疗侧改善更明显。总体而言，治疗前半身改良PASI评分中位数为4.4分，UVA治疗侧降至3.9分，安慰剂治疗侧降至4.2分（反应差异P = 0.044）。将斑块评分细分为红斑、鳞屑和厚度的各个组成部分，仅红斑评分有显著改善。尽管改善程度较小，但64%的患者认为反应足够好，他们会再次使用日光浴床治疗银屑病。
我们的结果表明，短期的日光浴床治疗确实能使部分患者的银屑病得到改善，但改善程度较小。
