Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Photochem Photobiol Sci. 2013 Jan;12(1):47-53. doi: 10.1039/c2pp25116g.
Ultraviolet B (UVB) is a highly effective, relatively safe, affordable and widely used therapeutic option for moderate psoriasis. Several types of UVB lamp are available to treat psoriasis, both broadband and narrowband, allowing a choice of spectral emission. However despite years of clinical use, the mechanism of action of UVB in clearing psoriasis remained incompletely understood. Moreover, there has been little insight into how the relative effectiveness of different UVB wavelengths linked to the mechanism of action, although it is known that the action spectrum for clearance of psoriasis differs from the action spectrum of erythema. This paper examines the existing literature from which our current treatments have evolved, and offers new insight into the use of keratinocyte apoptosis as a biomarker which may help to optimise UV treatment in the future. When combined with a systems biology approach, this potential biomarker may provide insight into which wavelengths of UV are the most effective in clearing psoriasis, allowing a more rational and potentially an individually tailored approach to optimising phototherapy for psoriasis.
中波紫外线（UVB）是一种高效、相对安全、经济实惠且广泛应用于中度银屑病治疗的选择。有多种类型的 UVB 灯可用于治疗银屑病，包括广谱和窄谱，可选择不同的光谱发射。然而，尽管临床应用多年，UVB 清除银屑病的作用机制仍不完全清楚。此外，对于不同 UVB 波长与作用机制相关的相对有效性，我们的了解甚少，尽管已知清除银屑病的作用光谱与红斑的作用光谱不同。本文研究了现有文献，这些文献为我们目前的治疗方法提供了新的见解，并提出了角质形成细胞凋亡作为生物标志物的新见解，这可能有助于优化未来的 UV 治疗。当与系统生物学方法结合使用时，这种潜在的生物标志物可能提供有关哪些 UV 波长对清除银屑病最有效的见解，从而为优化银屑病的光疗提供更合理且潜在的个体化方法。
