1型人类免疫缺陷病毒（HIV-1）、HIV-2和莫洛尼鼠白血病病毒中病毒基因组RNA分选机制的比较
Comparison of viral genomic RNA sorting mechanisms in human immunodeficiency virus type 1 (HIV-1), HIV-2, and Moloney murine leukemia virus.
作者信息
Dorman N, Lever A
机构信息
University of Cambridge Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.
出版信息
J Virol. 2000 Dec;74(23):11413-7. doi: 10.1128/jvi.74.23.11413-11417.2000.
Abstract
Genomic RNA sorting between translation and packaging was examined for human immunodeficiency virus type 1 (HIV-1) and HIV-2 using actinomycin D and leptomycin B treatment. Both viruses behaved differently from a simple retrovirus under actinomycin D treatment. With leptomycin B, the lack of apparent functional separation between translation and packaging functions in lentiviruses was confirmed. HIV-2 RNA levels were more stable, but reverse transcriptase production declined similarly to HIV-1.
摘要
利用放线菌素D和 leptomycin B处理，对1型人类免疫缺陷病毒（HIV-1）和HIV-2在翻译与包装之间的基因组RNA分选情况进行了研究。在放线菌素D处理下，这两种病毒的表现与简单逆转录病毒不同。使用leptomycin B时，证实了慢病毒在翻译和包装功能之间缺乏明显的功能分离。HIV-2的RNA水平更稳定，但逆转录酶的产生与HIV-1一样下降。
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