Edomwonyi N P, Obiaya M O, Imasuen S O, Weerasinghe A S
Department of Anaesthesia, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria.
West Afr J Med. 2000 Apr-Jun;19(2):132-6.
Co-induction is the concurrent administration of two or more drugs that facilitate induction of anaesthesia. Some combinations have been shown to have pharmacological advantages. In addition to the safety and comfort of the patient, it is also important to find a cost effective combination in view of the rather stringent economy of the times. This project was undertaken to study the response of Nigerian patients to co-induction (midazolam and propofol) by comparison with the traditional thiopentone or propofol alone, and to study the cost implications. 45 patients who came in for various surgical procedures were randomly assigned to three different groups. The first group was induced with thiopentone alone. The second group had a combination of midazolam and propofol and the third group had propofol alone. In all other respects except for the surgery the patients had the same treatment. The induction was satisfactory in all groups. The cardiovascular and respiratory changes were within clinically acceptable limits but the emergence was best with propofol, followed by midazolam/propofol and thiopentone in that order. Although thiopentone was the cheapest in terms of absolute cost, the combination of midazolam and propofol was most cost-effective.
联合诱导是指同时给予两种或更多种有助于麻醉诱导的药物。一些组合已显示出具有药理学优势。除了患者的安全性和舒适度外，鉴于当前经济形势较为严峻，找到一种具有成本效益的组合也很重要。开展该项目是为了通过与传统的单独使用硫喷妥钠或丙泊酚进行比较，研究尼日利亚患者对联合诱导（咪达唑仑和丙泊酚）的反应，并研究其成本影响。45名因各种外科手术前来就诊的患者被随机分为三组。第一组仅用硫喷妥钠诱导。第二组使用咪达唑仑和丙泊酚的组合，第三组仅用丙泊酚。除手术外，在所有其他方面患者接受相同的治疗。所有组的诱导均令人满意。心血管和呼吸变化在临床可接受范围内，但苏醒情况以丙泊酚最佳，其次是咪达唑仑/丙泊酚，硫喷妥钠排在最后。尽管就绝对成本而言硫喷妥钠最便宜，但咪达唑仑和丙泊酚的组合最具成本效益。
