Kohli-Seth R, Oropello J M
Department of Surgery, Mount Sinai Medical Center, City University of New York, New York, USA.
Crit Care Clin. 2000 Oct;16(4):557-78, vii-viii. doi: 10.1016/s0749-0704(05)70134-2.
Today's intensivists are provided with more information than ever before, yet current monitors present data from multiple sources in a relatively raw form with virtually no intelligent data integration and processing. In the next century, technological advances in miniaturization, biosensors and computer processing, coupled with an improved understanding of critical illnesses at the molecular level, will lead to the development of a new generation of monitors. Monitoring will move from the traditional macroscopic invasive approach to a noninvasive, molecular analysis of evolving critical disease processes. It is likely that disturbances in homeostasis will become known immediately or before they would otherwise be manifest clinically. Nanotechnology will permit monitoring of critical changes in the intracellular environment or the by-products of cellular metabolism and signal messaging. This article discusses monitoring technologies that hold promise for further development in the next century and point out techniques likely to be abandoned.
如今，重症监护医师可获取的信息比以往任何时候都多，但当前的监测设备以相对原始的形式呈现来自多个来源的数据，几乎没有智能数据整合和处理功能。在下个世纪，小型化、生物传感器和计算机处理方面的技术进步，再加上对危重病在分子水平上的深入理解，将催生新一代监测设备的研发。监测将从传统的宏观侵入性方法转向对不断演变的危重病过程进行非侵入性分子分析。内环境稳态的紊乱很可能会在临床上显现之前就被立即发现。纳米技术将能够监测细胞内环境的关键变化或细胞代谢及信号传递的副产品。本文讨论了有望在下个世纪进一步发展的监测技术，并指出了可能会被淘汰的技术。
