Ogawa Y, Miyazato T, Hatano T
Department of Urology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
World J Surg. 2000 Oct;24(10):1154-9. doi: 10.1007/s002680010193.
Calcium oxalate is a major component of renal stones, and its urinary concentration plays an important role in stone formation. Even a small increase in urinary oxalate has a significant impact on calcium oxalate saturation. Although primary hyperoxaluria is relatively uncommon, patients with calcium oxalate stones have some degree of hyperoxaluria. To understand the underlying causes of such hyperoxaluria, the processes of oxalate synthesis and excretion must be clarified. This article focuses on the determination of oxalate, calculation of its saturation, and the hyperoxaluric syndromes with special reference to metabolic precursors of oxalate, including ascorbic acid, glyoxylate, and glycolate.
草酸钙是肾结石的主要成分，其尿浓度在结石形成中起重要作用。即使尿草酸略有增加也会对草酸钙饱和度产生显著影响。虽然原发性高草酸尿症相对不常见，但草酸钙结石患者存在一定程度的高草酸尿症。为了解这种高草酸尿症的潜在原因，必须阐明草酸的合成和排泄过程。本文重点关注草酸的测定、其饱和度的计算以及高草酸尿症综合征，特别提及草酸的代谢前体，包括抗坏血酸、乙醛酸和乙醇酸。
