Hylander E, Jarnum S, Frandsen I
Scand J Gastroenterol. 1979;14(4):475-9.
The incidence of urolithiasis was registered in 87 patients with chronic inflammatory bowel disease and compared with that of renal oxalate excretion. All patients were studied while on a standardized diet with fixed amounts of fat, calcium, and oxalate. Pyelography had been performed in all. Nine, or 35%, of 26 hyperoxaluric patients had urolithiasis, compared with 14, or 23%, of 61 patients were normal renal oxalate excretion, the difference being statistically insignificant. No significant difference in urinary oxalate or urinary calcium in stone-formers as compared with non-stone-formers could be demonstrated. Oxalate was a more frequent component of calculi in patients with normal renal oxalate excretion than in patients with hyperoxalura. Thus, we were unable to demonstrate an increased incidence of urolithiasis in patients with hyperoxaluria compared with a control group with normal renal oxalate excretion. Our results cast doubt on the concept that enteric hyperoxaluria per se is the cause of stone diathesis in chronic inflammatory bowel disease.
对87例慢性炎症性肠病患者的尿石症发病率进行了登记，并与肾草酸排泄情况进行了比较。所有患者均在摄入固定脂肪、钙和草酸盐量的标准化饮食条件下接受研究。所有患者均进行了肾盂造影。26例高草酸尿症患者中有9例（35%）患有尿石症，而61例肾草酸排泄正常的患者中有14例（23%）患有尿石症，差异无统计学意义。与非结石形成者相比，结石形成者的尿草酸或尿钙无显著差异。肾草酸排泄正常的患者中，草酸盐在结石中的成分比高草酸尿症患者更常见。因此，与肾草酸排泄正常的对照组相比，我们未能证明高草酸尿症患者的尿石症发病率增加。我们的结果对肠道高草酸尿症本身是慢性炎症性肠病结石素质原因这一概念提出了质疑。
