Hutmacher D W
Institute of Engineering Science, Department of Orthopedic Surgery, National University of Singapore.
Biomaterials. 2000 Dec;21(24):2529-43. doi: 10.1016/s0142-9612(00)00121-6.
Musculoskeletal tissue, bone and cartilage are under extensive investigation in tissue engineering research. A number of biodegradable and bioresorbable materials, as well as scaffold designs, have been experimentally and/or clinically studied. Ideally, a scaffold should have the following characteristics: (i) three-dimensional and highly porous with an interconnected pore network for cell growth and flow transport of nutrients and metabolic waste; (ii) biocompatible and bioresorbable with a controllable degradation and resorption rate to match cell/tissue growth in vitro and/or in vivo; (iii) suitable surface chemistry for cell attachment, proliferation, and differentiation and (iv) mechanical properties to match those of the tissues at the site of implantation. This paper reviews research on the tissue engineering of bone and cartilage from the polymeric scaffold point of view.
肌肉骨骼组织、骨骼和软骨是组织工程研究中广泛研究的对象。许多可生物降解和可生物吸收的材料以及支架设计已通过实验和/或临床研究。理想情况下，支架应具有以下特性：（i）三维且高度多孔，具有相互连接的孔隙网络，以促进细胞生长以及营养物质和代谢废物的流动运输；（ii）生物相容性和生物可吸收性，降解和吸收速率可控，以匹配体外和/或体内的细胞/组织生长；（iii）适合细胞附着、增殖和分化的表面化学性质；（iv）机械性能与植入部位的组织相匹配。本文从聚合物支架的角度综述了骨和软骨组织工程的研究。
