Inoue-Sakurai C, Maruyama S, Morimoto K
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, Osaka, 565-0871, Japan.
Prev Med. 2000 Nov;31(5):467-73. doi: 10.1006/pmed.2000.0744.
The relationships among mental health status, lifestyle, and natural killer (NK) cell activity, which plays important roles in the immune surveillance of tumors and viral infections, were investigated in victims of the Hanshin-Awaji Earthquake.
About 1 and 1/3 years after the earthquake, 155 male workers who experienced the event were administered questionnaires concerning their unhealthy mental status, such as symptoms of posttraumatic stress disorder (PTSD), lifestyles, and demographic variables. Peripheral blood was taken from all of them to measure NK cell activity.
Subjects who had PTSD symptoms showed lower NK cell activity than those without symptoms. Subjects with positive lifestyles showed higher NK cell activity than those with poor or moderate lifestyles. When subjects were divided into four groups by lifestyle and PTSD symptoms, subjects with positive lifestyles and few or no PTSD symptoms showed the highest NK cell activity among the four groups. The other three groups were subjects with positive lifestyles but many PTSD symptoms; subjects with poor or moderate lifestyles and many PTSD symptoms; and subjects with poor or moderate lifestyles and few or no PTSD symptoms.
PTSD symptoms and lifestyles were associated with NK cell activity in the earthquake victims.
在阪神-淡路大地震的受害者中，研究了心理健康状况、生活方式与自然杀伤（NK）细胞活性之间的关系，NK细胞活性在肿瘤免疫监视和病毒感染中发挥着重要作用。
地震发生约1又1/3年后，对155名经历该事件的男性工人进行问卷调查，内容涉及他们的不良心理状态，如创伤后应激障碍（PTSD）症状、生活方式和人口统计学变量。采集他们所有人的外周血以测量NK细胞活性。
有PTSD症状的受试者NK细胞活性低于无症状者。生活方式积极的受试者NK细胞活性高于生活方式不良或一般的受试者。当根据生活方式和PTSD症状将受试者分为四组时，生活方式积极且PTSD症状少或无的受试者在四组中NK细胞活性最高。其他三组分别是生活方式积极但PTSD症状多的受试者；生活方式不良或一般且PTSD症状多的受试者；以及生活方式不良或一般且PTSD症状少或无的受试者。
PTSD症状和生活方式与地震受害者的NK细胞活性有关。
