McKeith I G
Department of Old Age Psychiatry, Institute for the Health of the Elderly, Wolfson Research Center, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.
Neurol Clin. 2000 Nov;18(4):865-902. doi: 10.1016/s0733-8619(05)70230-9.
Dementia occurs more commonly in individuals with Parkinson's disease (PD) than in the age-matched general population. Dementia in PD may result from a mixture of cortical and subcortical dementia syndromes caused by a variety of underlying pathologic processes and neurochemical deficits. A primary dementia syndrome has been described that shares several pathologic and clinical characteristics with PD. Dementia with Lewy bodies (DLB) accounts for 15% to 20% of all dementia syndromes in old age, which makes it second only to Alzheimer's disease in prevalence. The relationship between dementia in PD and DLB has not been fully resolved but may be considered useful in terms of neuropathologic substrate, clinical features, and response to treatment.
与年龄匹配的普通人群相比，帕金森病（PD）患者中痴呆的发生率更高。PD中的痴呆可能源于多种潜在病理过程和神经化学缺陷所导致的皮质和皮质下痴呆综合征的混合。已经描述了一种原发性痴呆综合征，它与PD具有一些病理和临床特征。路易体痴呆（DLB）占老年所有痴呆综合征的15%至20%，其患病率仅次于阿尔茨海默病。PD中的痴呆与DLB之间的关系尚未完全明确，但在神经病理基础、临床特征和治疗反应方面可能具有参考价值。
