额颞叶痴呆、其他类型痴呆及正常衰老情况下脑脊液中tau蛋白、β-淀粉样蛋白（1-42）和GAP-43的水平。
CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging.
作者信息
Sjögren M, Minthon L, Davidsson P, Clarberg A, Vanderstichele H, Vanmechelen E, Wallin A, Blennow K
机构信息
Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Mölndal, Sweden.
出版信息
J Neural Transm (Vienna). 2000;107(5):563-79. doi: 10.1007/s007020070079.
Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms.
对额颞叶痴呆（FTD，n = 17）、阿尔茨海默病（AD，n = 60）、皮质下白质痴呆（SWD，n = 24）、帕金森病（PD，n = 23）和心境恶劣（n = 19）患者以及年龄匹配的对照组（n = 32）的脑脊液（CSF）中tau蛋白、β-淀粉样蛋白（1-42）和生长相关蛋白43（GAP-43）水平进行了研究。仅在AD患者中CSF-tau显著升高，与对照组相比，AD和SWD患者的CSF-β-淀粉样蛋白（1-42）显著降低，且与FTD患者相比，AD患者的CSF-β-淀粉样蛋白（1-42）也显著降低。仅在PD患者中CSF-GAP-43显著降低。与对照组相比，除心境恶劣组外，所有患者组的GAP-43/tau比值均降低。所有组中CSF-GAP-43与CSF-tau之间均呈正相关。结果表明FTD患者的CSF-tau和CSF-β-淀粉样蛋白（1-42）水平正常，这将有助于FTD与AD的临床鉴别。在SWD中，CSF-β-淀粉样蛋白（1-42）水平降低提示血管和淀粉样蛋白机制同时受累。
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