Li Moyu, Gan Jinghuan, Yang Xia, Liu Shuai, Ji Yong
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Aging Neurosci. 2024 May 2;16:1390036. doi: 10.3389/fnagi.2024.1390036. eCollection 2024.
Abnormal cerebrospinal fluid (CSF)/serum albumin ratio (Qalb) levels have been observed in patients with cognitive impairment. Few studies have specifically focused on Lewy Body Disease (LBD), and the results were controversial. Thus, we conducted this systematic review and meta-analysis to investigate Qalb levels in patients with LBD by including data from different studies.
We systematically searched PubMed, Embase, Cochrane Library, and Web of Science databases for a collection of studies containing studies comparing Qalb levels in patients with LBD and healthy controls (including healthy controls and other dementia subtypes). In the initial search, 86 relevant papers were retrieved. Standardized mean differences (SMD) in Qalb levels were calculated using a random effects model.
A total of 13 eligible studies were included. Mean Qalb levels were significantly higher in patients with LBD compared to healthy older adults [standardized mean difference (SMD): 2.95, 95% confidence interval (CI): 0.89-5.00, = 2.81, = 0.005]; and were significantly higher in patients with LBD than in patients with Alzheimer's disease (AD) (SMD: 1.13, 95% CI: 0.42-1.83, = 3.15, = 0.002);whereas mean Qalb levels were significantly higher in patients with frontotemporal lobar degeneration (FTLD) compared to those with AD (SMD: 1.13, 95% CI,0.14-2.13, = 2.24, = 0.03).
Qalb levels were significantly elevated in LBD patients compared with normal older adults and were higher than those in AD patients and FTLD patients, which helped in the differential diagnosis of LBD from other neurodegenerative diseases.
https://www.crd.york.ac.uk/prospero/, identifier CRD42024496616.
认知障碍患者脑脊液（CSF）/血清白蛋白比值（Qalb）水平异常。很少有研究专门聚焦于路易体病（LBD），且结果存在争议。因此，我们进行了这项系统评价和荟萃分析，通过纳入不同研究的数据来调查LBD患者的Qalb水平。
我们系统检索了PubMed、Embase、Cochrane图书馆和Web of Science数据库，以收集包含比较LBD患者与健康对照（包括健康对照和其他痴呆亚型）Qalb水平的研究。在初步检索中，共检索到86篇相关论文。使用随机效应模型计算Qalb水平的标准化均值差（SMD）。
共纳入13项符合条件的研究。与健康老年人相比，LBD患者的平均Qalb水平显著更高[标准化均值差（SMD）：2.95，95%置信区间（CI）：0.89 - 5.00，Z = 2.81，P = 0.005]；与阿尔茨海默病（AD）患者相比，LBD患者的平均Qalb水平显著更高（SMD：1.13，95% CI：0.42 - 1.83，Z = 3.15，P = 0.002）；而与AD患者相比，额颞叶变性（FTLD）患者的平均Qalb水平显著更高（SMD：1.13，95% CI，0.14 - 2.13，Z = 2.24，P = 0.03）。
与正常老年人相比，LBD患者的Qalb水平显著升高，且高于AD患者和FTLD患者，这有助于LBD与其他神经退行性疾病的鉴别诊断。
