Semino O, Passarino G, Oefner P J, Lin A A, Arbuzova S, Beckman L E, De Benedictis G, Francalacci P, Kouvatsi A, Limborska S, Marcikiae M, Mika A, Mika B, Primorac D, Santachiara-Benerecetti A S, Cavalli-Sforza L L, Underhill P A
Dipartimento di Genetica e Microbiologia, Università di Pavia, Via Ferrata 1, 27100 Pavia, Italy.
Science. 2000 Nov 10;290(5494):1155-9. doi: 10.1126/science.290.5494.1155.
A genetic perspective of human history in Europe was derived from 22 binary markers of the nonrecombining Y chromosome (NRY). Ten lineages account for >95% of the 1007 European Y chromosomes studied. Geographic distribution and age estimates of alleles are compatible with two Paleolithic and one Neolithic migratory episode that have contributed to the modern European gene pool. A significant correlation between the NRY haplotype data and principal components based on 95 protein markers was observed, indicating the effectiveness of NRY binary polymorphisms in the characterization of human population composition and history.
欧洲人类历史的遗传学视角源自非重组Y染色体（NRY）的22个二元标记。在研究的1007条欧洲Y染色体中，10个谱系占比超过95%。等位基因的地理分布和年龄估计与两次旧石器时代和一次新石器时代的迁徙事件相符，这些事件为现代欧洲基因库做出了贡献。观察到NRY单倍型数据与基于95种蛋白质标记的主成分之间存在显著相关性，这表明NRY二元多态性在表征人类群体组成和历史方面的有效性。
