2,4-二取代哌啶的非对映选择性合成：药物发现的骨架
A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.
作者信息
Watson P S, Jiang B, Scott B
机构信息
Dupont Pharmaceuticals Company, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA.
出版信息
Org Lett. 2000 Nov 16;2(23):3679-81. doi: 10.1021/ol006589o.
PMID:11073674
Abstract
A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.
摘要
已开发出一种非对映选择性合成2,4-二取代哌啶的方法，该方法仅通过改变反应顺序就能完全控制反应选择性。这些目标化合物为药物研发提供了便利的平台，其中包含易于修饰的多样性位点。
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