Moses P, Courchesne E, Stiles J, Trauner D, Egaas B, Edwards E
Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA.
Cereb Cortex. 2000 Dec;10(12):1200-10. doi: 10.1093/cercor/10.12.1200.
This morphometric study examined two aspects of corpus callosum development: pediatric cortico-callosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five anterioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed a reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.
小儿皮质-胼胝体拓扑结构以及围产期脑损伤后的发育神经可塑性。利用活体磁共振成像对10名患有局灶性病变的儿童和86名健康志愿者对照者的胼胝体矢状面总横截面积及五个前后亚区进行了量化。10名早期受伤儿童中有9名的胼胝体总面积相对于匹配的对照组有所减小。胼胝体总横截面积与病变大小成反比。所有患者均表现出特定区域的缩小。这种区域变薄与病变部位存在拓扑关系。前亚区1、2和3的缩小分别与额下前区、额中及额上区以及中央前区的病变相关。亚区4的变细对应于顶叶前部病变，亚区5的变薄则发生于顶叶后部损伤时。这种皮质-胼胝体模式与成人及非人类灵长类动物的图谱一致。尽管病变早期就已出现，但胼胝体变薄表明发育神经可塑性存在局限性。
