Tatlidil R
Research Imaging Center, University of Texas Health Sciences Center, San Antonio, TX, USA.
Epilepsy Res. 2000 Dec;42(2-3):83-8. doi: 10.1016/s0920-1211(00)00135-2.
Four patients with complex partial seizure disorder whose positron emission tomography (PET) scans show sustained hyperperfusion of the epileptiform focus 12-24 h after a seizure episode are presented. Three of these patients underwent same day Fluorine-18 (18F) deoxyglucose (FDG) PET scans, which showed hypometabolism of the epileptic temporal lobe. In one patient who underwent repeated blood flow and concurrent glucose metabolism scans 4 days after a seizure, hyperperfusion was not present and the FDG-PET demonstrated hypometabolism. Persistent hyperperfusion was noted in six out of 65 cases studied. Four out of six patients who were followed clinically were presented in this report. The cause of the rare occurrence of persistent postictal or interictal hyperperfusion and the differences of postictal blood flow dynamics and glucose metabolism need to be clarified further with future studies.
本文报告了4例复杂部分性癫痫障碍患者，其正电子发射断层扫描（PET）显示在癫痫发作后12 - 24小时癫痫病灶持续灌注增加。其中3例患者在同一天进行了氟-18（18F）脱氧葡萄糖（FDG）PET扫描，显示癫痫发作的颞叶代谢减低。1例患者在癫痫发作4天后进行了重复血流和同步葡萄糖代谢扫描，未出现灌注增加，FDG - PET显示代谢减低。在所研究的65例病例中，有6例出现持续灌注增加。本报告介绍了6例临床随访患者中的4例。持续性发作后或发作间期灌注增加的罕见原因以及发作后血流动力学和葡萄糖代谢的差异，有待未来研究进一步阐明。
