Baba T, Sonozaki H, Seki K, Uchiyama M, Ikesawa Y, Toriisu M
J Immunol. 1976 Jan;116(1):112-6.
Tissue eosinophilia is often found in the inflammatory lesions of bullous perphigoid. A study made on naturally occurring eosinophil chemotactic activity in the blister fluids of four bullous pemphigoid patients revealed the existence of this activity in all of them. Sephadex G-25 column chromatography showed that the greater part of this eosinophil chemotactic activity was composed of low molecular substance of which the weight was close to that of vitamin B12 (m.w. 1357). The blister fluids and the sera of these patients contained elevated levels of IgE. An IgE anti-skin basement, membrane antibody was found in two if the four sera, and deposits of IgE were detected along the basement membrane zone of the involved skin in one of the patients. On the basis of these findings, we have reason to believe that an eosinophil chemotactic factor of anaphylaxis (ECF-A) participates in the accumulation of eosinophils in the lesions of bullous pemphigoid.
在大疱性类天疱疮的炎性损害中常可见组织嗜酸性粒细胞增多。一项针对4例大疱性类天疱疮患者水疱液中自然存在的嗜酸性粒细胞趋化活性的研究表明，所有患者均存在这种活性。葡聚糖G - 25柱层析显示，这种嗜酸性粒细胞趋化活性的大部分由低分子物质组成，其分子量接近维生素B12（分子量1357）。这些患者的水疱液和血清中IgE水平升高。在4份血清中的2份中发现了IgE抗皮肤基底膜抗体，并且在其中1例患者的受累皮肤基底膜区检测到了IgE沉积。基于这些发现，我们有理由相信过敏反应嗜酸性粒细胞趋化因子（ECF - A）参与了大疱性类天疱疮皮损中嗜酸性粒细胞的聚集。
