1型糖尿病和肥胖儿童的血清瘦素水平：与胰岛素水平的关系。

Serum leptin levels in type 1 diabetic and obese children: relation to insulin levels.

作者信息

Kirel B, Doğruel N, Korkmaz U, Kiliç F S, Ozdamar K, Uçar B

机构信息

Department of Pediatrics, Osmangazi University Faculty of Medicine, Eskişehir, Turkey.

出版信息

Clin Biochem. 2000 Aug;33(6):475-80. doi: 10.1016/s0009-9120(00)00136-3.

DOI:10.1016/s0009-9120(00)00136-3

PMID:11074239

Abstract

OBJECTIVES

To compare serum leptin levels in type 1 diabetic and obese children.

DESIGN AND METHODS

We studied serum leptin levels in 35 type 1 diabetic, 32 obese, and 35 healthy children. Seven of 35 were new-onset diabetics with ketoacidosis. C-peptide (CPE) levels were used for estimating insulin secretion.

RESULTS

Serum leptin levels were lower in diabetics than in controls (p<0.001). Obese children had higher leptin and CPE levels than diabetics and controls. In new-onset diabetics, 1 month insulin treatment did not cause any change in leptin levels (p>0.05). Leptin was correlated positively with body mass index and CPE (p<0.001) and inversely with glucose (p = 0.001) and HbA1c (p<0.05) in the combined group. HbA1c and gender were the independent predictors of leptin in diabetic children (p<0.01).

CONCLUSIONS

Low serum leptin levels in type 1 diabetic children may be due to chronic insulin deficiency related with their metabolic control. Leptin and insulin may have complementary roles in maintaining a stable body weight.

摘要

目的

比较1型糖尿病儿童和肥胖儿童的血清瘦素水平。

设计与方法

我们研究了35名1型糖尿病儿童、32名肥胖儿童和35名健康儿童的血清瘦素水平。35名中有7名是新发糖尿病并伴有酮症酸中毒的患儿。使用C肽（CPE）水平来评估胰岛素分泌。

结果

糖尿病患儿的血清瘦素水平低于对照组（p<0.001）。肥胖儿童的瘦素和CPE水平高于糖尿病患儿和对照组。在新发糖尿病患儿中，1个月的胰岛素治疗未引起瘦素水平的任何变化（p>0.05）。在合并组中，瘦素与体重指数和CPE呈正相关（p<0.001），与血糖（p = 0.001）和糖化血红蛋白（p<0.05）呈负相关。糖化血红蛋白和性别是糖尿病患儿瘦素的独立预测因素（p<0.01）。