Dayem Soha M Abd El, Kader Mona Abd El, Ibrahim Soheir, Mokhtar Enas, Megeed Eman Abd El
Pediatrics Department, National Research Centre, Cairo, Egypt.
Clinical Pathology Department, National Research Centre, Cairo, Egypt.
Open Access Maced J Med Sci. 2017 Mar 19;5(2):131-136. doi: 10.3889/oamjms.2017.033. eCollection 2017 Apr 15.
To evaluate leptin and lipid profile in overweight patients with type 1 diabetes.
The study included 50 overweight patients with type 1 diabetes and 50 age and sex matched healthy controls. Blood samples were taken for evaluation of glycosylated haemoglobin, lipid profile and leptin. Also, urine samples were taken for evaluation of albumin/creatinine ratio.
Leptin level was significantly lower in overweight with type 1 diabetes and showed a significant positive correlation with hip circumference and body mass index and negative correlation with glycosylated haemoglobin (HbA1c). Leptin level was significantly lower in overweight diabetic patients with HbA1c > 7.5 %. The best cut-off point between overweight diabetic group and control group regarding leptin levels was found at 16.9 (ng/ml) with a sensitivity of 68% and specificity of 56%, area under the curve 0.623.
Leptin levels were found to be low in overweight patients with type 1 diabetes and showed correlation with the body mass index and hip circumference. LDL was significantly higher while HDL was significantly lower in the diabetic, overweight group indicating increased risk of cardiovascular disease. Leptin level in overweight diabetic patients might be related to the metabolic control.
评估1型糖尿病超重患者的瘦素和血脂水平。
该研究纳入了50例1型糖尿病超重患者以及50例年龄和性别匹配的健康对照者。采集血样以评估糖化血红蛋白、血脂水平和瘦素。此外，采集尿样以评估白蛋白/肌酐比值。
1型糖尿病超重患者的瘦素水平显著降低，且与臀围和体重指数呈显著正相关，与糖化血红蛋白（HbA1c）呈负相关。HbA1c>7.5%的超重糖尿病患者的瘦素水平显著更低。超重糖尿病组与对照组之间瘦素水平的最佳切点为16.9（ng/ml），敏感性为68%，特异性为56%，曲线下面积为0.623。
发现1型糖尿病超重患者的瘦素水平较低，且与体重指数和臀围相关。糖尿病超重组的低密度脂蛋白显著更高，而高密度脂蛋白显著更低，表明心血管疾病风险增加。超重糖尿病患者的瘦素水平可能与代谢控制有关。
