Krout K E, Loewy A D
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
J Comp Neurol. 2000 Dec 18;428(3):475-94. doi: 10.1002/1096-9861(20001218)428:3<475::aid-cne6>3.0.co;2-9.
The projections from the parabrachial nucleus to the midline and intralaminar thalamic nuclei were examined in the rat. Stereotaxic injections of the retrograde tracer cholera toxin-beta (CTb) were made in each of the intralaminar nuclei of the dorsal thalamus (the lateral parafascicular, medial parafascicular, oval paracentral, central lateral, paracentral, and central medial nuclei), as well as the midline thalamic nuclei (the paraventricular, intermediodorsal, mediodorsal, paratenial, rhomboid, reuniens, parvicellular part of the ventral posterior, and caudal ventral medial nuclei). The retrograde cell body labeling pattern within the parabrachial subnuclei was then analyzed. The paracentral thalamic nucleus received an input only from the internal lateral parabrachial subnucleus. However, this subnucleus also projected to all the other intralaminar thalamic nuclei, except for the central lateral thalamic nucleus, which received no parabrachial afferent inputs. The external lateral parabrachial subnucleus projected to the lateral parafascicular, reuniens, central medial, parvicellular part of the ventral posterior, and caudal ventromedial thalamic nuclei. Following CTb injections in the paraventricular thalamic nucleus, retrogradely labeled cells were found in the central lateral, dorsal lateral, and external lateral parabrachial subnuclei. The medial and ventral lateral parabrachial subnuclei projected to the oval paracentral, parafascicular, and rhomboid thalamic nuclei. Finally, the waist area of the parabrachial nucleus was densely labeled after CTb injections in the parvicellular part of the ventral posterior thalamic nucleus. Nociceptive, visceral, and gustatory signals may reach specific cortical and other forebrain sites via this parabrachial-thalamic pathway.
在大鼠中研究了臂旁核向中线和丘脑板内核的投射。将逆行示踪剂霍乱毒素β（CTb）立体定位注射到背侧丘脑的每个板内核（外侧束旁核、内侧束旁核、中央旁椭圆形核、中央外侧核、中央旁核和中央内侧核）以及中线丘脑核（室旁核、中间背核、背内侧核、缰旁核、菱形核、连合核、腹后核小细胞部和尾侧腹内侧核）。然后分析臂旁亚核内的逆行细胞体标记模式。中央旁丘脑核仅接受来自外侧臂旁内侧亚核的输入。然而，该亚核也投射到所有其他丘脑板内核，但中央外侧丘脑核除外，它没有接受臂旁传入输入。外侧臂旁外侧亚核投射到外侧束旁核、连合核、中央内侧核、腹后核小细胞部和尾侧腹内侧丘脑核。在室旁丘脑核注射CTb后，在中央外侧、背外侧和外侧臂旁外侧亚核中发现了逆行标记的细胞。内侧和外侧臂旁腹侧亚核投射到中央旁椭圆形核、束旁核和菱形丘脑核。最后，在腹后丘脑核小细胞部注射CTb后，臂旁核的腰部区域被密集标记。伤害性、内脏和味觉信号可能通过这条臂旁 - 丘脑通路到达特定的皮质和其他前脑部位。
