Metter K, Glöser H, von Gaisberg U
Klinik für Allgemeine Innere Medizin, Gastroenterologie und Hepatologie, Stuttgart-Bad Cannstatt, Tübingen.
Dtsch Med Wochenschr. 2000 Sep 29;125(39):1160-3. doi: 10.1055/s-2000-7666.
A 42-year-old man who had just returned from a trip to Turkey presented with recurrent right upper abdominal pain and bouts of fever. Physical examination was unremarkable except for an enlarged liver on palpation.
There was a slight increase in tests indicating cholestasis and in transminases. There was a marked eosinophilia of 57% in the differential blood count. Ultrasound examination indicated an inhomogeneous and enlarged right lobe of the liver with a 2.5 x 3 cm poorly circumscribed echo-poor space-occupying lesion. Computed tomography demonstrated multiple hypodense foci. Needle biopsy revealed a histological picture suggesting parasite infection.
DIAGNOSIS, TREATMENT AND COURSE: The patient was referred to a department of tropical medicine. His symptoms progressed and the antibody titre for Fasciola hepatica was increased, but no Fasciola eggs were found in the stool. Administration of triclabendazole resulted in lasting regression of the symptoms and a dramatic fall in eosinophilia to ultimately 6%.
In eosinophilia of undetermined origin parasitic infection should be considered and any previous visit to countries with endemic parasitic disease taken into account.
一名刚从土耳其旅行归来的42岁男子,出现右上腹反复疼痛和发热。体格检查除触诊时肝脏肿大外无异常。
提示胆汁淤积的检查及转氨酶略有升高。血常规分类计数显示明显的嗜酸性粒细胞增多,占57%。超声检查显示肝脏右叶不均匀肿大,有一个2.5×3厘米、边界不清的低回声占位性病变。计算机断层扫描显示多个低密度灶。针吸活检显示组织学图像提示寄生虫感染。
诊断、治疗及病程:患者被转诊至热带医学科。其症状进展,肝片吸虫抗体滴度升高,但粪便中未发现肝片吸虫卵。服用三氯苯达唑后症状持续缓解,嗜酸性粒细胞显著下降,最终降至6%。
对于不明原因的嗜酸性粒细胞增多,应考虑寄生虫感染,并考虑患者既往是否去过寄生虫病流行国家。