Beliaeva N F, Gorodetskiĭ V K, Tochilkin A I, Golubev M A, Semenova N V, Kovel'man I R
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences.
Vopr Med Khim. 2000 Jul-Aug;46(4):344-60.
Vanadium compounds as insulin mimics with promising therapeutic properties are reviewed. The biological effects of both inorganic forms of vanadium and vanadyl organic complexes are decried for various animal models. These effects include hypoglycemic and insulin reserve actions, insulin sensitivity enhance, cholesterol lowering and other manifestations. The effectiveness of vanadium compounds in diabetes treatment is confirmed with clinical trials. The possible mechanisms of insulin-like effects of vanadium are discussed. The various nutritional supplements for patients with diabetes mellitus including vanadium-contained used in Russia and abroad are also considered.
综述了具有潜在治疗特性的钒化合物作为胰岛素模拟物的情况。阐述了无机形式的钒和钒基有机配合物对各种动物模型的生物学效应。这些效应包括降血糖和胰岛素储备作用、增强胰岛素敏感性、降低胆固醇及其他表现。钒化合物在糖尿病治疗中的有效性已通过临床试验得到证实。讨论了钒类似胰岛素作用的可能机制。还考虑了俄罗斯国内外用于糖尿病患者的各种营养补充剂，包括含钒的补充剂。
