Orvig C, Thompson K H, Battell M, McNeill J H
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Met Ions Biol Syst. 1995;31:575-94.
That vanadium compounds act in an insulin-mimetic fashion both in vitro and in vivo has been well established. Both inorganic and organic vanadium compounds have been shown to lower plasma glucose levels, increase peripheral glucose uptake, improve insulin sensitivity, decrease plasma lipid levels, and normalize liver enzyme activities in a variety of animal models of both type I and type II diabetes. Vanadium treatment of diabetic animals does not restore plasma insulin levels but may spare pancreatic insulin. Elucidation of the mechanism(s) of action and potentiation of vanadium's insulin-mimetic effect by appropriate ligand binding would seem to be the highest priorities for future investigation.
钒化合物在体外和体内均以胰岛素模拟方式发挥作用，这一点已得到充分证实。在I型和II型糖尿病的多种动物模型中，无机和有机钒化合物均已显示出可降低血糖水平、增加外周葡萄糖摄取、改善胰岛素敏感性、降低血脂水平并使肝酶活性恢复正常。对糖尿病动物进行钒治疗并不能恢复血浆胰岛素水平，但可能会节省胰腺胰岛素。阐明钒的作用机制以及通过适当的配体结合增强其胰岛素模拟效应，似乎是未来研究的首要任务。
