Ghose T, Guclu A, Tai J
J Natl Cancer Inst. 1975 Dec;55(6):1353-7. doi: 10.1093/jnci/55.6.1353.
A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody. Exposure of the lymphoma cells to chlorambucil-bound antibody caused greater tumor inhibition both in vitro and vivo than did the synergistic effect of exposure seperately to the antibody and chlorambucil.
一种针对自发起源的AKR小鼠淋巴瘤的细胞表面定位异种抗体，可以与苯丁酸氮芥结合，而不会干扰苯丁酸氮芥的烷基化活性或抗体的免疫反应性。与单独暴露于抗体和苯丁酸氮芥的协同效应相比，将淋巴瘤细胞暴露于与苯丁酸氮芥结合的抗体在体外和体内均能产生更强的肿瘤抑制作用。
