Guclu A, Tai J, Ghose T
Immunol Commun. 1975;4(3):229-42. doi: 10.3109/08820137409055776.
A rabbit 7 S antibody reacting specifically with a tumor assoicated antigen on the surface of mouse EL4 lymphoma cells could form "caps" and subsequently undergo endocytosis even when the antibody was non-covalently bound to chlorambucil. As the alkylation of nuclear DNA appears to be the basis of tumor inhibition by alkylating agents like chlorambucil, facilitation of the transport of chlorambucil across cell membrane by anti-tumor antibodies might explain, at least in part, the increased tumor inhibition by cholorambucil bound anti-tumor antibodies compared to tumor inhibition by equivalent amounts of tumor antibodies or chlorambucil alone.
一种能与小鼠EL4淋巴瘤细胞表面肿瘤相关抗原特异性反应的兔7S抗体，即使该抗体与苯丁酸氮芥非共价结合，也能形成“帽”并随后发生内吞作用。由于核DNA的烷基化似乎是像苯丁酸氮芥这样的烷基化剂抑制肿瘤的基础，抗肿瘤抗体促进苯丁酸氮芥跨细胞膜的转运可能至少部分解释了与等量肿瘤抗体或单独的苯丁酸氮芥相比，苯丁酸氮芥结合的抗肿瘤抗体对肿瘤抑制作用增强的原因。
