Knowles S R, Uetrecht J, Shear N H
Department of Medicine, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Ontario, Canada.
Lancet. 2000 Nov 4;356(9241):1587-91. doi: 10.1016/S0140-6736(00)03137-8.
Idiosyncratic drug reactions are unpredictable reactions that can result in significant morbidity and mortality. Severe reactions are often characterised by fever and internal organ involvement. Despite progress in the identification of reactive metabolites believed to be the cause of idiosyncratic reactions, the basic mechanisms remain elusive. Furthermore, because of the lack of consensus regarding definition of these syndromes, reporting, and therefore epidemiological data, are often unreliable. Research is needed to explore further the pathophysiology of these reactions, so that better diagnostic tests and treatment methods can be developed.
特异质药物反应是不可预测的反应，可导致严重的发病率和死亡率。严重反应通常以发热和内脏器官受累为特征。尽管在确定被认为是特异质反应原因的反应性代谢产物方面取得了进展，但其基本机制仍然难以捉摸。此外，由于对这些综合征的定义缺乏共识，报告以及因此的流行病学数据往往不可靠。需要开展研究以进一步探索这些反应的病理生理学，从而开发出更好的诊断测试和治疗方法。
