Sinsawaiwong S, Thampanitchawong P
Department of Medicine, Prince of Songkla University, Thailand.
J Med Assoc Thai. 2000 Sep;83(9):1124-6.
A 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demyelinating polyneuropathy. Other potential causes of Guillain-Barre' syndrome (GBS) were ruled out. Her motor power gradually improved and returned to normal later. The temporal relationship between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this very rare complication are proposed with a literature review.
一名17岁女性在3天前接种重组乙型肝炎疫苗后出现进行性四肢瘫，并伴有双侧面瘫。脑脊液分析显示无细胞液且蛋白水平升高。电诊断结果与脱髓鞘性多发性神经病相符。格林-巴利综合征（GBS）的其他潜在病因已被排除。她的运动能力逐渐改善，后来恢复正常。GBS与疫苗接种之间的时间关系提示为疫苗诱导所致。结合文献综述，提出了这种极为罕见并发症的发病机制。
