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重组乙型肝炎疫苗接种后发生的格林-巴利综合征及文献综述

Guillain - Barre' syndrome following recombinant hepatitis B vaccine and literature review.

作者信息

Sinsawaiwong S, Thampanitchawong P

机构信息

Department of Medicine, Prince of Songkla University, Thailand.

出版信息

J Med Assoc Thai. 2000 Sep;83(9):1124-6.

Abstract

A 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demyelinating polyneuropathy. Other potential causes of Guillain-Barre' syndrome (GBS) were ruled out. Her motor power gradually improved and returned to normal later. The temporal relationship between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this very rare complication are proposed with a literature review.

摘要

一名17岁女性在3天前接种重组乙型肝炎疫苗后出现进行性四肢瘫,并伴有双侧面瘫。脑脊液分析显示无细胞液且蛋白水平升高。电诊断结果与脱髓鞘性多发性神经病相符。格林-巴利综合征(GBS)的其他潜在病因已被排除。她的运动能力逐渐改善,后来恢复正常。GBS与疫苗接种之间的时间关系提示为疫苗诱导所致。结合文献综述,提出了这种极为罕见并发症的发病机制。

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