Tarakji B, Ashok N, Alakeel R, Azzeghaibi Sn, Umair A, Darwish S, Mahmoud Rs, Elkhatat E
Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing, Riyadh, Saudi Arabia.
Department of Clinical Laboratory Sciences, King Saud University, Alfarabi College of Medicine, Riyadh, Saudi Arabia.
Ann Med Health Sci Res. 2014 Nov;4(6):829-36. doi: 10.4103/2141-9248.144870.
Hepatitis B vaccine has been administered in children and adults routinely to reduce the incidence of the disease. Even though, hepatitis B vaccine is considered as highly safe, some adverse reactions have been reported. A literature search was carried out in PubMed, accessed via the National Library of Medicine PubMed interface, searching used the following keywords: Hepatitis B vaccine and complications from 1980 to 2014. A total of 1147 articles were obtained out of which articles, which discuss the complications occurring orally or occurring elsewhere in the body, which have the potential to manifest orally after hepatitis B vaccination were selected. A total of 82 articles were identified which included 58 case series or case reports, 15 review articles, 4 cross sectional studies, 3 prospective cohort studies, one retrospective cohort study and a case control study. After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder. Of these complications, some are manifested orally or have the potential to manifest orally. Although, most of the complications are self-limiting, some are very serious conditions, which require hospitalization with immediate medical attention.
乙肝疫苗已常规接种于儿童和成人，以降低该疾病的发病率。尽管乙肝疫苗被认为是高度安全的，但仍有一些不良反应的报道。通过美国国立医学图书馆的PubMed界面在PubMed上进行了文献检索，检索使用了以下关键词：1980年至2014年的乙肝疫苗及并发症。共获得1147篇文章，从中选择了讨论口服或身体其他部位出现的并发症的文章，这些并发症在接种乙肝疫苗后有可能在口腔表现出来。共确定了82篇文章，其中包括58个病例系列或病例报告、15篇综述文章、4项横断面研究、3项前瞻性队列研究、1项回顾性队列研究和1项病例对照研究。在查阅文献后，我们观察到接种乙肝疫苗后出现的并发症有婴儿猝死综合征、多发性硬化症、慢性疲劳综合征、特发性血小板减少性紫癜、血管炎性视神经炎、过敏反应、系统性红斑狼疮、扁平苔藓和神经肌肉疾病。在这些并发症中，有些在口腔表现出来或有可能在口腔表现出来。虽然大多数并发症是自限性的，但有些是非常严重的情况，需要住院并立即接受医疗护理。
