Maggi P, de Mari M, Moramarco A, Fiorentino G, Lamberti P, Angarano G
Infectious Diseases Clinic, University of Bari, Italy.
Neurol Sci. 2000 Jun;21(3):173-6. doi: 10.1007/s100720070093.
The localization of opportunistic infections in the basal ganglia in patients with acquired immunodeficiency syndrome (AIDS) can cause movement disorders, such as choreoathetosis, dystonia, hemiballism and, more rarely, parkinsonism. We describe the case of an AIDS patient who developed cerebral opportunistic granulomatous lesions and, subsequently, a parkinsonian akinetic-rigid syndrome. In agreement with cases reported in the literature, the parkinsonian syndrome developed only when the lesions bilaterally involved basal ganglia. The critical localization of the opportunistic lesions in the direct and indirect strio-pallidal pathways possibly associated with the HIV-related neurotoxicity might have contributed to determine this clinical picture.
获得性免疫缺陷综合征（AIDS）患者基底神经节的机会性感染定位可导致运动障碍，如舞蹈指划样动作、肌张力障碍、偏身投掷症，较少见的还有帕金森症。我们描述了1例AIDS患者，该患者出现了脑部机会性肉芽肿病变，随后发展为帕金森氏运动不能-强直综合征。与文献报道的病例一致，帕金森综合征仅在双侧基底神经节受累的病变发生时才出现。机会性病变在可能与HIV相关神经毒性有关的直接和间接纹状体-苍白球通路中的关键定位，可能促使了这一临床症状的出现。
