Department of Experimental Pathology, M.B.I.E., School of Medicine, Università di Pisa, Via Roma, 55 Pisa, Italy.
Neurol Sci. 2013 Apr;34(4):417-25. doi: 10.1007/s10072-012-1197-4. Epub 2012 Sep 26.
Toxoplasmosis is a widespread infection, with clinical spectrum ranging from a completely asymptomatic infection to multi-organ involvement. After entering the body, the parasite forms tissue cysts and establishes a chronic infection, involving also the central nervous system (CNS). During the last years, a lot of research has focused on the possible link between exposure to T. gondii and development of neuropsychiatric disorders such as schizophrenia and Parkinson's disease (PD). If a firm association between Toxoplasma infection and neuropsychiatric disorders will be established, this would lead to novel strategies for their prevention and treatment. We will review data from serological and neurodevelopment studies relating infection with T. gondii to such neuropsychiatric diseases.
弓形体病是一种广泛存在的感染，其临床表现范围从完全无症状感染到多器官受累。寄生虫进入人体后，会形成组织囊肿并建立慢性感染，也会涉及中枢神经系统（CNS）。在过去的几年中，大量的研究集中在接触弓形体和发展神经精神疾病（如精神分裂症和帕金森病（PD））之间的可能联系上。如果能确定弓形体感染与神经精神疾病之间的关联，这将为它们的预防和治疗提供新的策略。我们将回顾与感染弓形体相关的血清学和神经发育研究的数据，以了解这些神经精神疾病。
