Khajehdehi P, Jamal J A, Bastani B
Department of Internal Medicine, Saint Louis University School of Medicine, MO, USA.
Clin Nephrol. 2000 Oct;54(4):351-5.
We present a critically ill patient with severe renal failure and anuria who underwent hemodialysis (HD), continuous veno-venous hemodialysis (CVVHD) and continuous veno-venous hemodiafiltration (CVVHDF) at different occasions, with 2 commonly used high-efficiency dialyzers (F-8 and CA-210), while receiving i.v. acyclovir. We estimate that during 24 hours of CVVHD with F-8 dialyzer approximately 18% and during 24 hours of CVVHDF with CA-210 dialyzer approximately 65% of the daily administered acyclovir is removed. This is comparable to the amount removed during 4 6 hours of HD, as reported previously. The percentage acyclovir extraction was 84% and 60% during CVVHD and CVVHDF with F-8 and CA-210 dialyzers, respectively. Acyclovir clearance during CVVHD was 14 ml/min and during CVVHDF was 17 ml/min, with F-8 and CA-210 dialyzers, respectively. Acyclovir half-life was 22.5 and 25.5 hours in 2 occasions off any type of renal replacement therapy, and it was 19.5 hours during CVVHDF with CA-210 dialyzer.
我们报告了一名患有严重肾衰竭和无尿的重症患者，该患者在不同时间接受了血液透析（HD）、连续性静脉-静脉血液透析（CVVHD）和连续性静脉-静脉血液滤过透析（CVVHDF），使用了2种常用的高效透析器（F-8和CA-210），同时接受静脉注射阿昔洛韦治疗。我们估计，在使用F-8透析器进行24小时CVVHD期间，每日给予的阿昔洛韦约有18%被清除；在使用CA-210透析器进行24小时CVVHDF期间，约有65%被清除。这与先前报道的在4至6小时HD期间清除的量相当。在使用F-8和CA-210透析器进行CVVHD和CVVHDF期间，阿昔洛韦的提取率分别为84%和60%。使用F-8和CA-210透析器时，CVVHD期间阿昔洛韦的清除率分别为14 ml/min和CVVHDF期间为17 ml/min。在未进行任何类型肾脏替代治疗的2个不同时段，阿昔洛韦的半衰期分别为22.5小时和25.5小时，而在使用CA-210透析器进行CVVHDF期间，半衰期为19.5小时。
